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TRENTON, N.J. — U.S. regulators on Friday accustomed a fast-acting, super-potent opioid book as an addition to IV painkillers acclimated in hospitals.

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The accommodation by the Food and Biologic Administration came over objections from critics who abhorrence the us will be abused. In a diffuse statement, FDA Commissioner Scott Gottlieb said there will be “very bound restrictions” placed on its administration and it is advised alone for supervised settings like hospitals.

The tiny us was developed as an advantage for patients who affectation difficulties for the use of IVs, including soldiers on the battlefield. The us from AcelRx Pharmaceuticals contains the aforementioned decades-old painkiller generally accustomed in IV anatomy or bang to surgical patients and women in labor.

Gottlieb acclaimed the us was a aerial antecedence for the Department of Defense, which helped armamentarium testing, because it capital a way to accommodate fast affliction abatement to afflicted soldiers. The tablet, placed beneath the argot with a dispenser, starts abbreviation affliction in 15 to 30 minutes.

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A console of FDA admiral had beforehand voted 10-3 in favor of the us alleged Dsuvia (duh-SOO’-vee-uh). But in a attenuate response, the panel’s administrator aing critics in advancement the FDA to adios it. The chairman, Dr. Raeford E. Brown Jr., who couldn’t appear the affair and didn’t casting a vote, predicts that the us will be abused central and alfresco medical settings and account balance deaths.

The pills accommodate sufentanil, a actinic accessory of the opioid fentanyl.

Gottlieb said the biologic will backpack a boxed admonishing and won’t be accessible at drugstores for patients to booty home. Acknowledging the criticism, he said he’s asked FDA agents to “evaluate a new framework” for the approval of new opioid drugs that will acutely outline how the bureau considers allowances and risks.

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“We won’t abstain what I accept is the absolute basal antecedent of depression amid the critics of this approval — the catechism of whether or not America needs addition able opioid while in the affliction of a massive crisis of addiction,” Gottlieb’s wrote.

Sidney Wolfe of Public Citizen’s Health Research Group, a customer group, alleged Gottlieb’s account “empty rhetoric” and said the bureau absent a big befalling back it accustomed the pill.

“It’s a huge mistake,” Wolfe said. “This biologic is doomed. It’s alarming and it will annihilate people.”

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The Redwood City, California-based aggregation expects the us to be accessible aboriginal aing year at a amount of $50 to $60 per pill.

In one study, the us provided about the aforementioned affliction abatement to patients as IV morphine. Common ancillary furnishings with Dsuvia included nausea, ing, ache and decreased claret oxygen levels. Those occurred hardly added generally with the us than for abstraction participants accustomed morphine.

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Follow Linda A. Johnson on Twitter: @LindaJ_onPharma

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AP Medical Writer Carla K. Johnson contributed from Seattle.

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The Associated Press Health & Science Department receives abutment from the Howard Hughes Medical Institute’s Department of Science Education. The AP is alone amenable for all content.

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